Introduction of Bis (Trifluoromethyl) Cadmium 1, 2 Dimethoxymethane

        Into organic or inorganic the incorporation of fluoroalkyl group substrates frequently results in materials that have different properties like mechanical, biological as well as biological, for a given application that are much more desirable than those of the parent compound. Such as pyrimidine nucleosides the 5-trifluoromethyl are known as inhibitor significantly tumor growth. By the reaction these species are readily synthesized with appropriate halouracil derivatives along with the  organometallics compound.

        For the syntheses the suitable reagent is derivatives from the group IIB of organometallics compounds that contain the perfluoroalkyl ligands.  The mercurial, such as, halides of several group react with mercurial and form compound like    using the mercurial ligand exchange reaction, moreover, elevated temperature typically required as well as the reaction time is long. Although  NMR approach to the group of element in a basic solvents like pyridine the reaction had been isolated no product formed.

        Based on the observation that we followed the procedure the compounds like methyl, trifluoromethyl, as well as mixed methyl these sort of species  are present in the mixture that is formed when it react with the  Lewis base adduct is known as the compound  under vacuum it does not undergo dissociation;  the isolation as well as purification is readily accomplished.

Experiment of Bis (Trifluoromethyl) Cadmium 1, 2 Dimethoxymethane

        By sublimation  is purified at ambient temperature of torr, to condense allowing the sublimate onto the cooled surface to -10 degree. The successful synthesizes of  from the thermal decarboxylation  these are obtained at least twice prior the sublimed should be used. Over sodium benzophenone ketyl as well as degassed Glyme 1, 2-dimethoxyethane is dried at least two thaw cycles of freeze pump is used. From the reaction of the methyl Grignard along with cadmium (II) Dimethyl cadmium could be prepared.

        In a clean dry freshly sublimed  is placed there in a 50mL round bottomed flask, and a stirring bar magnetic. With a vacuum the flask is fitted stopcock to one end that affixed the joint 24/40; to the other end of the stopcock an 18/9 ball joint is sealed. To a standard vacuum line the flask is attached through the connection of ball-and-socket. Into the reaction vessel approximately 10mL of purified Glyme is vacuum distilled. From -196 degree as the substances of the flask are allowed to warm, for several minutes they ought to be stirred magnetically certify the complete dissolution .

        1.44g  has dissolved the , vacuum distillation during the reaction vessels. For 2.3 hour the solution is stirred at ambient temperature. Slowly the solution turned into cloudy during this time as to form the . Under vacuum the volatile material is removed but 12 hour is required for this procedure and a white free flowing power is remained behind the flask. Until the solid is thoroughly dry the content of the vessels are then pumped as we described above the product is treated. The yield is 57 percent.

Table: For Lewis base Adducts   NMR data

    Through two methods the Lewis base adducts of  could be easily synthesized. By utilizing THF a procedure analogous to the above is the first method, pyridine (py) as well as the yield of different components are 50, 70 percent respectively. For the reaction to proceed the following significant time is required. For 19 hour equilibrium THF used as a solvent. Direct Lewis Base Exchange method is the other simplest method. When it dissolved in the excess amount of pyridine gives the 96 percent yield.

Result & Discussion of Bis (Trifluoromethyl) Cadmium 1, 2 Dimethoxymethane

        In ethers and haloalkanes the compound  is soluble, economically in arenes are soluble, as well as in alkanes insoluble. Under  the product stored is best otherwise at low temperature Ar, meanwhile thermal decomposition, 5% day, at ambient temperature. The first preparation of the group 5A organometallics perfluoromethyl has grown steadily. Sophisticated methodology is required for synthesizes of completely substituted compounds such as reactors of metal atom discharge techniques, at elevated temperature prolonged interaction of the reagents. Electropositive metals formation highly substituted derivatives for example  with the only reagent known to be effective through the ligand exchange reaction.

        It is discussed that in a dry Glyme from the excess of   as well as CdMe₂ BIS (trifluoromethyl) cadmium.glyme was best formed. Under high vacuum by prolonged pumping after 3hour all volatile material is removed. It soluble in the ethers as well as haloalkanes. At the end we get the yield of 95 to 96 percent. There is the following precaution that we should follow during the experiments. As in an efficient hood the dimethyl cadmium is a noxious smelling, toxic liquid that might be handled with the care.  It is completely dry and might be spontaneously ignite in air. Under inert condition all the times  could be handled that is recommended (KRAUSE & MORRISO, 1980).

Conclusion of Bis (Trifluoromethyl) Cadmium 1, 2 Dimethoxymethane

        It is concluded that with the help of the Bis (Trifluoromethyl) Cadmium 1, 2 Dimethoxyethane we get the required solution of . By far the most convenient bis (trifluoromethyl) cadmium.glyme is known for the preparation of trifluoromethyl substituted, under the ambient conditions the reaction is required only some minutes. It is also concluded that we get the yield 57, or 96 percent. Under further studies the mechanism of the reaction along with the acyl halides, yet the fluorides quickly formed and at low temperatures excellent yield is obtained. It also concluded that the in other systems thermal generation of CF₂ is required at much lower temperature  is the clearly transfer reagent.

References of Bis (Trifluoromethyl) Cadmium 1, 2 Dimethoxymethane