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Spinal Code Injury
The
article “Delivery of Neostigmine and
Glycopyrrolate by Iontophoresis” is based on the collaborative group
research study conducted by the Korsten and his
group fellows in 2018. the research studied the individuals with spinal code
injury as non-randomized study. the article provide information about the
problems related to the Spinal code functionality. Down regulation of the
para-sympathetic neural pathway causes the activity of intestinal peristaltic
to slow down. the situation is direclty associated with the injury in spinal
code.
The article provide information regarding the
methodology of non- randomaized study used to address the issue. In accordance
to the researchers the methodology was used after the approval of Institutional
review Board of JJPVAMC. in the research selected population was between the
age of 15- 50. The research has reported the side effects as the headache,
drowsiness, dry mouth, abdominal cramping and eye/facial twiching. other than
all these no other serious side effect was reported
The research elaborate that the cholinergic effect on
Colon caused by the Neo can be controlled and reduced in the sensitive
individual by the anticholinergic actions of GLY. while in accordance to the
article the BM follows the adminstration of NEO. patient having the
neurological injury faces the state of spasm of the anal-sphincter. the digital
stimulation in such type of patients can cause for the imporvement of BM
likelihood towards following the administration of NEO.
The article also provide recommendation regarding the
drug combination. according to the article the without having the clear
demonstration towards the safety of drug combination an individual should not
consider the GLY/NEO free from any risk. to induce the BM is in the patients of
spinal code injury the best option is NEO/GLY administrated by the TD. The TD
adminstrating the NEO/GLY are relatively safe for the individuals.
References of Spinal Code Injury
|
[1] |
M. A. Korsten, B. L.
Lyons, M. Radulovic, T. M. Cummings, G. Sikka, K. Singh, J. C. Hobson, A.
Sabiev, A. M. Spungen and W. A. Bauma, "Delivery of neostigmine and
glycopyrrolate by iontophoresis: a nonrandomized study in individuals with
spinal cord injury," Spinal cord, vol. 56, no. 3, p. 212, 2018. |
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