Introduction of These immune cells

These immune cells play a major role for defending the error cells that are present in the living body. These cells also protect from any infection and cancer cells. If immune cells are strong so it means your immune system is extremely strong and it will help the living body for spreading the cancerous cells. Through the help of dangerous signals these type of cells undergoes to activate the basic function of the immune cells. From different studies it can be seen that these immune cells upon activation different metabolic changes happened and that will affect the cancer cells. Also, it can be seen that these activated immune cells may affect their contribution to cancerous cells progression (Muralidharan-Chari, Clancy and Sedgwick).  

The role of immune cells in cancer Therapy

From the recent studies it can be seen that the main role of tumor is related to macrophages, these tumor cells are also associated with neutrophils. All of these cells have a great impact on the production of tumor cells like cytokines and chemokine. Also the products that is made from such cells have some important role for defining the role of tumor cell metastasis. One of the systemic disease known as Neoplasm in which all the cancer cells acts as the leading devil. That will participate in inappropriate activation of the tumor cells in the living body (K., Graham and Fraser.).

Immune cells dual roles and their factors that are involved in cancer development and progression

There are two main roles of immune system like immune surveillance and immunoediting that are involved in increasing the development of tumor cells. Through this behavior many unresolved immune responses can be seen like chronic inflammation. These are involved promoting the progression and growth of the cancerous cells. It can be seen that these immune cells with their some factors that are produce from them that include inflammatory cytokines, they always play a dual role in promoting the cancer cells in the living body. Due to this they play a major role in the progression of cancer cells (Lu, Weaver and Werb).

The role of immunity cells in suppressing and promoting the cancer cells

For immunology one of the most challenging question is about the understanding about how immune cells are involved in affecting the cancer development. Form different research it is concluded that the immune cells plays dual role in cancer like they are involved in suppressing the growth of tumor cells from growing through destroy it, and also these cells are involved in promoting the cancerous cells through dual host protection  role (Schreiber, Old and Smyth.).

Complexity of microenvironment tumor: important role for cancer therapy

            From the research it can be seen that tumor microenvironment mainly consist of that particular cells that have soluble factors, extracellular matrix. Mechanical cuse and signaling molecules and these are involved in promoting the neoplastic transformation, invasion, protection for tumor and also support the growth of tumor. There are five different concepts that has been used for understanding the complexity of tumor microenvironment (Zamarron and Chen)

Conclusion on These immune cells

            Summing up all the discussion from above it is concluded that the immune cells plays a major role in promoting and damaging the cancerous cells in the living body. These are involved promoting the progression and growth of the cancerous cells. It can be seen that these immune cells with their some factors that are produce from them that include inflammatory cytokines, they always play a dual role in promoting the cancer cells in the living body.  

Reference of These immune cells

K., R. J. Nibbs Oleinika, G. J. Graham and A. R. Fraser. "Suppression, subversion and escape: the role of regulatory T cells in cancer progression." Clinical & Experimental Immunology (2013): 36-45.

Lu, Pengfei, Valerie M. Weaver and Zena Werb. "The extracellular matrix: a dynamic niche in cancer progression." J Cell Biol (2012): 395-406.

Muralidharan-Chari, Vandhana, et al. "Microvesicles: mediators of extracellular communication during cancer progression." J Cell Sci 123 (2010): J Cell Sci 123.

Schreiber, Robert D., Lloyd J. Old and Mark J. Smyth. "Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion." Science 331 (2011): 1565-1570.

Zamarron, Brian F. and WanJun Chen. "Dual roles of immune cells and their factors in cancer development and progression." International journal of biological sciences (2011): 651.