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1Concepts of Pharmacology-Half Life Calculation-C. M. Prada, MDJuly 12, 2006
2•Pharmacokinetics = availability-dosage and rate of administration-modes of transport –across biologic membranes; bound to proteins from plasma and tissues-blood flow to the site of action-extent and speed of the metabolic process of the drug-rate of the removal of the drug (and its metabolic products)•Pharmacodynamics = pharmacologic effect (in relation with the plasma drug concentration)-cellular mechanisms of drug action-clinical evaluation of drug effects-biologic variability
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