Loading...

Messages

Proposals

Stuck in your homework and missing deadline? Get urgent help in $10/Page with 24 hours deadline

Get Urgent Writing Help In Your Essays, Assignments, Homeworks, Dissertation, Thesis Or Coursework & Achieve A+ Grades.

Privacy Guaranteed - 100% Plagiarism Free Writing - Free Turnitin Report - Professional And Experienced Writers - 24/7 Online Support

Extracting salicylic acid from willow bark experiment

27/03/2021 Client: saad24vbs Deadline: 2 Day

Abstract

Aspirin is an over the counter, nonsteroidal anti- inflammatory drug that can temporarily relieve symptoms such as migraines, aches, and pain. It can also prevent blood clots or reduce the risks of having a heart attack. In this experiment we used willow bark, ethanol, iron chloride, acetylsalicylic acid, salicylic acid, acetic acid, and an aspirin tablet in order to synthesize aspirin. Salicylic acid had the pH of 5 with lower acidity. Salicylic acid, is less acidic which means its less harmful to the stomach when compared to aspirin tablets because the tablet have higher acidity (pH 3) which can cause damage to the stomach lining if too acidic.

Introduction

With an estimated world-wide consumption of 40[thin space (1/6-em)]000 metric tons per year, aspirin (acetylsalicylic acid) which was discovered in 1853, is still one of the most prominent and widely used medicines with an incredible spectrum of properties. 1 Apart from its exceptional analgesic, anti-pyretic, and anti-inflammatory properties, it is commonly used in the primary and secondary prevention of cardiovascular diseases. 2

Aspirin is typically administered via the oral route, but unfortunately possesses a number of undesired side effects in long-term use that are mainly related to its acidity and low bioavailability. Aspirin is only sparingly soluble in water (0.33 g in 100 mL) or in the acidic environment of the stomach, resulting in undissolved particles adhering to the gastrointestinal mucosea and causing topical irritation and gastric distress. 3 Once absorbed in the small intestine, acetylsalicylic acid is rapidly metabolized to its main metabolite salicylic acid , thereby irreversibly acetylating and inhibiting COX-1 oxygenase. 4 Like aspirin , salicylic acid itself is also part of the non-steroidal anti-inflammatory drug (NSAID) family and is frequently found in a wide range of medical and cosmetic formulations such as skin-care products or sunscreens. 5 Apart from problems related to the poor solubility of aspirin , the bitter taste of acetylsalicylic acid is another major drawback, with the required dosage of aspirin leading to tablets that are notoriously hard to swallow.

Procedure

The experiment was completed in triplicate meaning steps done in well A1, were also done in B1 and C1. The materials used were a 24- well plate, pipettes, willow bark, litmus paper, ethanol, iron chloride, acetylsalicylic acid, salicylic acid, acetic acid and an aspirin tablet. In part 1 the procedure, consisted of the extraction of salicylic acid. In the first step of Part 1, A1 on the 24-well plate was half-filled with willow bark then the pipette was used to cover the bark with ethanol. A timer was set to 15 minutes to allow the bark to soak. In Part 2 of the experiment 0.5g of acetylsalicylic acid was added to well A2 on the 24-well plate. 50 drops of the ethanol was added with a pipette using the end of the pipette to stir after the ethanol was placed in all three wells. Thereafter each solution was then tested with litmus paper. In part 3 of the experiment, using a pipette one drop of iron chloride solution was added to the acetylsalicylic acid along with the salicylic acid mixtures in wells A2 and A3. In part 4 of the experiment a pipette was used to extract the ethanol from the willow bark in A1 once the 15 minutes were up. 5 drops of ethanol was added to well A4, then the ph was tested with the result of 5. Lastly 1 drop of iron chloride was added to well A1. In part 5 of the experiment using a pipette 5 drops of the willow bark ethanol was added to well A4 following 1drop of iron chloride and 15 drops of acetic acid then stirred with the end of the pipette. The observation was a strong vinegar like smell and brown color to the solution. In part 6 of the experiment an aspirin was crushed and weighed (2.24g). 0.25g of crushed aspirin was poured into well A6, and 50 drops of ethanol was added and stirred into well A6. The pH of the mixture was tested and resulted in pH4. Lastly one drop of iron chloride was added to the well changing the mixtures color from white to light yellow.

Results

The results for part 2 pH determination, acetylsalicylic acid in well A2 was 3. The pH of salicylic acid in well A3 was 3. The weight of acetylsalicylic acid in wells A1 was .53735 g, B2 was .5005 and C3 was .5020.The weight of salicylic acid in well A3 was .5049, well B3 WAS .5013, and well C3 was .5020. For part 3 the iron chloride test, the color of the acetylsalicylic acid solution was yellow in well A2 and the salicylic acid solution was dark purple in well A3.

For part 4 salicylic acid determination the pH of well A4 was 5. After 1 drop of iron chloride was added into the wells the solution turned from white clear to a light yellow color. For part 5 the synthesis of aspirin a strong smell of vinegar was produced after the acetic acid was added into well A5 cause a color change of brown. For part 6 comparison of aspirin tablets the pH of the mixture in well A6 was 4 and after 1 drop of iron chloride was added it turned into a yellowish white color.

Conclusion questions

Triplicate is having 3 copies of , experiments are done in triplicate so that if there is an error in the experiment all samples won’t be ruined and they are more likely to be correct with less room for error. Salicylic acid proved to be more irritating to the stomach due to the higher pH compared to the weak pH of the aspirin. The chemical structure of salicylic acid is (CH6O3) and acetylsalicylic acid is (C9H8O4). The salicylic acid and the salicylic acid that was extracted from the willow bark differ in acidity because of the extraction method used to get the salicylic acid from the willow bark. The salicylic acid had the pH of 3 and the willow bark had a pH of 6. The aspirin synthesis was successful because the color change and odor indicated a chemical reaction. The synthesized aspirin compares to the aspirin tablet because they both contain salicylic acid. In conclusion salicylic acid is and active ingredient in willow bark and aspirin but the willow bark solution had a pH of 6 making it the least acidic compared the aspirin tablet which had a pH of 4.

Homework is Completed By:

Writer Writer Name Amount Client Comments & Rating
Instant Homework Helper

ONLINE

Instant Homework Helper

$36

She helped me in last minute in a very reasonable price. She is a lifesaver, I got A+ grade in my homework, I will surely hire her again for my next assignments, Thumbs Up!

Order & Get This Solution Within 3 Hours in $25/Page

Custom Original Solution And Get A+ Grades

  • 100% Plagiarism Free
  • Proper APA/MLA/Harvard Referencing
  • Delivery in 3 Hours After Placing Order
  • Free Turnitin Report
  • Unlimited Revisions
  • Privacy Guaranteed

Order & Get This Solution Within 6 Hours in $20/Page

Custom Original Solution And Get A+ Grades

  • 100% Plagiarism Free
  • Proper APA/MLA/Harvard Referencing
  • Delivery in 6 Hours After Placing Order
  • Free Turnitin Report
  • Unlimited Revisions
  • Privacy Guaranteed

Order & Get This Solution Within 12 Hours in $15/Page

Custom Original Solution And Get A+ Grades

  • 100% Plagiarism Free
  • Proper APA/MLA/Harvard Referencing
  • Delivery in 12 Hours After Placing Order
  • Free Turnitin Report
  • Unlimited Revisions
  • Privacy Guaranteed

6 writers have sent their proposals to do this homework:

Professional Accountant
University Coursework Help
Homework Tutor
Professional Coursework Help
Assignment Hut
Study Master
Writer Writer Name Offer Chat
Professional Accountant

ONLINE

Professional Accountant

Give me a chance, i will do this with my best efforts

$106 Chat With Writer
University Coursework Help

ONLINE

University Coursework Help

You can award me any time as I am ready to start your project curiously. Waiting for your positive response. Thank you!

$36 Chat With Writer
Homework Tutor

ONLINE

Homework Tutor

I am known as Unrivaled Quality, Written to Standard, providing Plagiarism-free woork, and Always on Time

$106 Chat With Writer
Professional Coursework Help

ONLINE

Professional Coursework Help

I am known as Unrivaled Quality, Written to Standard, providing Plagiarism-free woork, and Always on Time

$110 Chat With Writer
Assignment Hut

ONLINE

Assignment Hut

Hello, I an ranked top 10 freelancers in academic and contents writing. I can write and updated your personal statement with great quality and free of plagiarism

$94 Chat With Writer
Study Master

ONLINE

Study Master

Give me a chance, i will do this with my best efforts

$90 Chat With Writer

Let our expert academic writers to help you in achieving a+ grades in your homework, assignment, quiz or exam.

Similar Homework Questions

Wgu workforce planning task 2 - High speed opto isolator - Strong base weak nucleophile - Sacred mexican kitchen mernda - Wk7 DQ1 2 Assgn - Toyota - Hypothesis Testing - The kiss that missed book - Leadership in organizations yukl 8th edition ppt - Rams home loan application form - Info Tech Mini Project - 2019 standard maths hsc - Deli3 - What makes a good student council - We shall remain after the mayflower worksheet answers - Spelling city com login - How to calculate equivalent annual value - Religion and Ethics - Anchor woods switches price list 2016 - Gomez runs a small pottery firm - ATI written assignment - Following are transactions of danica company - Yukl g 2013 leadership in organizations - Wave on a string worksheet answers - Rkfree setup 226 password 123 - Spanish preposiciones - Calculate gdp as the value added in production pizzania - Chicano - Improving family relationships - Persuasive Essay - Come gather round people wherever you roam - Language devices in persuasive writing - The sea of monsters summary - 2-4 pg paper - Baker c 2006 foundations of bilingual education and bilingualism - Universal mca music publishing - Cost accounting involves the measuring recording and reporting of - Nib core extras cover - Hx heart murmur icd 10 - CIS450 Assignment Mod 3: - Yogita limaye kashmir - David brooks one nation slightly divisible - Unit 1 DB: Psychological Perspectives - Where To Buy Dainty Jewelry - Oracle cloud applications price list - Persuasive speech outline on smoking - How do you envision the future of healthcare, and what role do you see yourself playing in shaping it? - 2 examples of neolithic myths - Jaycar 1080p action camera - How to date a brown girl - You got a ticket in your hand essay - Catastrophe theory sport psychology - Cyber security naics code - Brave new world quotes - I need care plan about anorexia - Virtualbox convert raw image to vdi - Research paper on the Access control for Data storage in Clouds - Topic 1: Accounting Research and the Codification -2 - What's the highest compatibility score on eharmony - Derivative of x 2 16 - Trevor off key i love my light - Boogie bounce bibra lake - 450 strathfield to hurstville - Lion king tickets playhouse square - MA_D2 - Mantis tiller oil level - What is this passage mostly about - Pssp hierarchy of needs - Masinde muliro university of science & technology - Global Crime & Justice - 8/2 - Labor Relations and Management Review and Reflection - Geo 3030 - Nonfiction writing can be trusted to be true true false - 6 feet 4 inches in meters - An example of a persuasive message - QUIZ - Total cost of merchandise purchased - According to philosopher john locke, which of the following statements about human rights is true? - Free blank mar sheets - Soap Note Assignment - Carbon black feedstock msds - Where do bandicoots sleep - 7739 zilli dr tracy ca - Vsphere 6.7 affinity rules - Chem 121 predicting products of chemical reactions answers - 100 Word Question(Needs to be done in 5 hours) - Igolder encrypt - Microsoft official academic course microsoft project 2016 pdf - Copper hydroxide and sodium nitrate heated - Marketing Strategies New England College - Unit 2 working in the science industry - Compose a 3-page paper-Persuading for Social Change - Acap login student portal - Weekly reflection - Modern database management by jeffrey a hoffer pdf free download - Mater christi uniform shop - Away from home rate youth allowance - Number of primes less than 10000 - Discussion