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Investigators at Department of Surgical Oncology Zero in on Colon Cancer (MicroRNA-184 inhibits cell proliferation and metastasis in human colorectal cancer by directly targeting IGF-1R)

Obesity, Fitness & Wellness Week . (Oct. 7, 2017): p2303.

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2017 OCT 7 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Oncology - Colon Cancer have been published. According to news reporting out of Jiangsu, People's Republic of China, by NewsRx editors, research stated, "Colorectal cancer is currently the third most common cancer in males and the second in females worldwide. In spite of marked progress having been achieved in surgical resection, radiotherapy and chemotherapy, the prognosis for patients with colorectal cancer remains poor."

Our news journalists obtained a quote from the research from the Department of Surgical Oncology, "Previous studies have demonstrated that the abnormal expression of microRNAs contributed to human cancer carcinogenesis and progression, suggesting miRNAs as novel therapeutic targets in colorectal cancer. The aim of the present study was to investigate the expression, functions and underlying molecular mechanisms of microRNA-184 (miR-184) in colorectal cancer. The results identified that miR-184 was significantly downregulated in colorectal cancer tissues and cell lines. functional studies demonstrated that miR-184 significantly inhibited colorectal cancer cell proliferation, migration and invasion. Notably, insulin-like growth factor 1 receptor (IGF-1R) was identified as a direct target of miR-184 in colorectal cancer. Furthermore, the functions of IGF-1R small interfering RNA were similar to those induced by miR-184 in colorectal cancer, suggesting IGF-1R as a functional target of miR-184 in colorectal cancer."

According to the news editors, the research concluded: "The results of the present study indicated that miR-184 may be a novel therapeutic strategy regimen of targeted therapy for colorectal cancer."

For more information on this research see: MicroRNA-184 inhibits cell proliferation and metastasis in human colorectal cancer by directly targeting IGF-1R. Oncology Letters, 2017;14(3):3215-3222.

Our news journalists report that additional information may be obtained by contacting G. Wu, Dept. of Surgical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, People's Republic of China. Additional authors for this research include J. Liu, Z. Wu, X. Wu and X. Yao.

Keywords for this news article include: Asia, Jiangsu, Genetics, Oncology, Colon Cancer, Gastroenterology, Cell Proliferation, Colorectal Research, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

The citation for this news report is: NewsRx. Investigators at Department of Surgical Oncology Zero in on Colon Cancer (MicroRNA-184 inhibits cell proliferation and metastasis in human colorectal cancer by directly targeting IGF-1R). Obesity, Fitness & Wellness Week. October 7, 2017; p 2303.

Source Citation (MLA 8th Edition)

"Investigators at Department of Surgical Oncology Zero in on Colon Cancer (MicroRNA-184 inhibits cell proliferation and metastasis in human colorectal cancer by directly targeting IGF-1R)." Obesity, Fitness & Wellness Week, 7 Oct. 2017, p. 2303. Health Reference Center Academic, http://link.galegroup.com/apps/doc/A507516778/HRCA?u=oran95108&sid=HRCA&xid=cf5bb66a. Accessed 9 Dec. 2017.