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The following sentences describe chromatin structure and how altering chromatin structure can affect gene expression. Complete each sentence using the words provided In some cells, DNA combines with proteins to form a substance called. The lowest level of chromatin structure consists of DNA wrapped twice around a group of his tones to form a(n).The formation of nucleosomes may block the binding of transcription factors and RNA polymerase II to the.The structure of chromatin can be modified by altering either the DNA or the attached to DNA. Large chromatin-remodeling complexes alter the structure of chromatin in order to make the DNA accessible to regulatory proteins which in turn, affect gene expression. In vertebrates, methylation of ensures that once a gene is turned off, it stays off. The of histones is correlated with tighter coiling of the DNA and inactive regions of chromatin. The of histones tends to loosen the coiling of DNA, making it more accessible for transcription. Chromatin is present in cells only. Chromatin that contains highly condensed DNA which is not being expressed is called Chromatin that contains loosely coiled DNA, which is accessible for transcription, is called Tighter coiling of the chromatin makes the DNA accessible for transcription
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